Keratoconus: Matrix metalloproteinase-2 activation and TIMP modulation
نویسندگان
چکیده
منابع مشابه
Total Hip Arthroplasty Matrix Metalloproteinase TIMP ANALYSIS OF MEMBRANE TYPE 1 - MATRIX METALLOPROTEINASE, MATRIX METALLOPROTEINASE-2 AND TISSUE INHIBITOR OF METALLOPROTEINSE-2 IN LOOSE HIP PERIPROSTHETIC CONNECTIVE TISSUES
Introduction: The biocompatibility of total hip prostheses has been the subject of debate for three decades, and currently it appears evident that the loosening of technically well inserted prostheses is in part due to cellular responses in periprosthetic connective tissues. Despite of intensive research, the precise biological mechanisms responsible for the loosening of total hip joints have n...
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Background: Meningioma is one of the most common tumors of the central nervous system. It was shown that meningioma had up-regulated expression of Matrix Metalloproteinases (MMPs) that involved in cell growth, angiogenesis and metastasis. Objectives: The aim of the study was the assessment of serum MMP-2 and -9 levels in patients with different grades of meningioma. Materials & Me...
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متن کاملPeptide from the C-terminal domain of tissue inhibitor of matrix metalloproteinases-2 (TIMP-2) inhibits membrane activation of matrix metalloproteinase-2 (MMP-2).
Cellular activation of latent matrix metalloproteinase-2 (proMMP-2) requires formation of a cell membrane-associated activation complex that involves specific binding between the hemopexin domain of proMMP-2 (PEX) and the C-terminal domain of tissue inhibitor of matrix metalloproteinases-2 (C-TIMP-2). In this study, we tested the feasibility of inhibiting activation of proMMP-2 by exogenous inh...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
سال: 2006
ISSN: 0925-4439
DOI: 10.1016/j.bbadis.2006.01.010